NEW YORK - APRIL 22: NFL Commissioner Roger Goodell speaks at the podium on stage during the first round of the 2010 NFL Draft at Radio City Music Hall on April 22, 2010 in New York City. (Photo by Jeff Zelevansky/Getty Images)
| PICK | TEAM | PLAYER |
| 2-14(46) | New York Giants | Linval Joseph, DT - ECU |
| 2-15(47) | Arizona Cardinals | Daryl Washington, LB - TCU |
| 2-16(48) | Carolina Panthers | Jimmy Clausen, QB - Notre Dame |
| 2-17(49) | San Francisco 49'ers | Taylor Mays, DB - USC |
| 2-18(50) | Kansas City Chiefs | Javier Arenas, CB - Alabama |
| 2-19(51) | Minnesota Vikings | Toby Gerhart, RB - Stanford |
| 2-20(52) | Pittsburgh Steelers | Jason Worilds, DE - VT |
| 2-21(53) | New England Patriots | Jermaine Cunningham, DE - Florida |
| 2-22(54) | Cincinnati Bengals | Carlos Dunlap, DE - Florida |
| 2-23(55) | Dallas Cowboys | Sean Lee, ILB - Penn State |
| 2-24(56) | Green Bay Packers | MIke Neal, DT - Purdue |
| 2-25(57) | Baltimore Ravens | Terrence Cody, DT - Alabama |
| 2-26(58) | Houston Texans | Ben Tate, RB - Auburn |
| 2-21(59) | Cleveland Browns |
Montario Hardesty, RB - Tennessee |
| 2-22(60) | Seattle Seahawks | Golden Tate, WR - Notre Dame |
| 2-23(61) | New York Jets | Vladimir Ducasse, OT - UMass |
| 2-24(62) | New England Patriots | Brandon Spikes, LB - Florida |
| 2-25(63) | Indianapolis Colts | Pat Angerer, LB - Iowa |
| 2-26(64) | New Orleans Saints | Charles Brown, OT - USC |
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