Emmanuel Sanders ruled out with a concussion

Sanders has been ruled out for remainder of game for #Broncos.

— Jeff Legwold (@Jeff_Legwold) November 16, 2014

Bubba Caldwell is his replacement, and behind him, the Broncos are very thin (Latimer is inactive). Jacob Tamme has already played most of the game with Julius Thomas out, and while there have been some one on one's, Manning seems to target Tamme at the most in-opportune times (go route down the sideline on a 3rd and 3).

With no running game to speak of and a 9-point deficit heading into the 4th quarter, Demaryius Thomas and Bubba Caldwell will have to step up.

Sanders recorded his 6th 100-yard receiving game on the season and caught a long touchdown on a post pattern behind busted coverage before halftime. He went down early in the 3rd quarter when he collided shoulder to shoulder with safety Rodney McLeod.