Broncos vs. Colts odds: Can Peyton Manning beat his old team on the road?

The Denver Broncos (7-0) will travel to face the Indianapolis Colts (3-5) in Week 9, and they'll be slight favorites on the road, a condition in which they've already won four games this year.

According to the latest NFL odds, the Broncos are 4.5-point favorites against the Colts in Indy, a line that has moved in Denver's direction since opening as three-point favorites.

But there are a handful of factoids trending against the Broncos approaching this fourth Peyton Manning rematch:

• Peyton Manning is 1-2 vs. the Colts despite being favored every time.
• The Broncos were 6.5-point favorites for Manning's original homecoming in 2013; the Broncos lost by six. The Broncos were eight-point favorites against the Colts at home in the playoffs this past January; the Colts beat the Broncos by 11.
• The Broncos are 0-5 against the Colts in Indianapolis in their last five visits, both against the spread and straight up.

"They're playing at home, so they have that advantage," Broncos cornerback Chris Harris Jr. said Monday, telling The Denver Post that he plans on covering T.Y. Hilton this time around. "They've had our number. It's something that we know that we've got to definitely get back on to the win column versus the Colts."

The Broncos will try just that, as favorites against Indy once again.